Meclizine vs ondansetron

A few OTC treatments are available that can be helpful in relieving nausea, vomiting, and dizziness. Dimenhydrinate (Dramamine) and meclizine (Bonine) are perennial favorites for treating symptoms associated with motion sickness. Emetrol (consisting of dextrose, fructose, and phosphoric acid), can be effective in treating nausea.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day.Dexamethasone, ondansetron or placebo (normal saline) was infused intravenously over a 10‐minute period in Stork 2006. A single oral dose of ondansetron was administered in Freedman 2006 and Roslund 2008, while in Ramsook 2002 participants received six doses over 48 hours and in Yilmaz 2010 three oralEmetrol has an average rating of 8.5 out of 10 from a total of 50 ratings on Drugs.com. 80% of reviewers reported a positive effect, while 10% reported a negative effect. Zofran has an average rating of 8.0 out of 10 from a total of 267 ratings on Drugs.com. 76% of reviewers reported a positive effect, while 16% reported a negative effect.Ondansetron orally disintegrating tablet is used to prevent nausea and vomiting caused by certain medical treatments. This medication is available as a generic drug and as the brand-name drug ...Key takeaways: Several medications can help with nausea from motion sickness. They work best when taken ahead of time to prevent symptoms from happening in the first place. Options include prescription scopolamine patches (Transderm Scop) and over-the-counter antihistamine pills, like dimenhydrinate (Dramamine) and meclizine (Bonine).Background: This study aimed to compare the therapeutic efficacy of dimenhydrinate and metoclopramide in patients with nausea and vertigo. Methods: A prospective, double-blind, randomized clinical trial was performed on patients who presented to the emergency department (ED) with nausea and vertigo in the six month period between Nov 1st 2012 and May 1st 2013.The recommended adult oral dosage of ZOFRAN is 24 mg given as three 8-mg tablets administered 30 minutes before the start of single-day highly emetogenic chemotherapy, including cisplatin 50 mg/m. 2. Multiday, single-dose administration of a 24 mg dosage has not been studied. Pediatric Use:

A retrospective study of ondansetron's emergency department use for pediatric migraine patients confirmed that glaring absence, noting that the research so far has focused on the antidopaminergics like metoclopramide (Reglan) and prochlorperazine (Compazine). ( Pediatr Neurol. 2020;103:52.) Meanwhile, despite its better side effect profile ...More about Meclizine. Ratings & Reviews. Emetrol for Nausea has an average rating of 10.0 out of 10 from a total of 2 ratings on Drugs.com. 100% of reviewers reported a positive effect, while 0% reported a negative effect. Meclizine has an average rating of 7.4 out of 10 from a total of 225 ratings on Drugs.com. 68% of reviewers reported a ...Less Serious Side Effects. Restlessness. Dry, itchy, or red eyes. Skin rash or redness. Dry mouth. Learn about Scopolamine: What it is used for, how to take Scopolamine, serious side effects, food and drug interactions, forms, doses, safe storage, and FAQs.Metoclopramide has an average rating of 3.9 out of 10 from a total of 514 ratings on Drugs.com. 29% of reviewers reported a positive effect, while 64% reported a negative effect. Phenergan has an average rating of 7.3 out of 10 from a total of 147 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 23% reported a negative ...Ondansetron is frequently used to treat nausea and vomiting during pregnancy, ... cyclizine, or meclizine) 1,19 (using a 1:1 ratio in a propensity-score-matched analysis). Meclizine has an average rating of 7.4 out of 10 from a total of 225 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 19% reported a negative effect. Dramamine Less Drowsy has an average rating of 9.5 out of 10 from a total of 3 ratings on Drugs.com. 100% of reviewers reported a positive effect, while 0% reported a ...

It is also used to prevent nausea and vomiting that may occur after surgery. Ondansetron works in the stomach to block the signals to the brain that cause nausea and vomiting. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Tablet, Disintegrating.Ondansetron and meclizine are used to prevent nausea and vomiting. Ondansetron is mainly used to prevent nausea and vomiting caused by cancer chemotherapy and after surgery. Meclizine is used to treat and prevent vertigo, dizziness, and motion sickness. Ondansetron (Zofran) vs. metoclopramide (Reglan)Ondansetron is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy), radiation treatment, or drugs used to put you to sleep before surgery.Ondansetron works by blocking one of the body's natural substances that causes vomiting.Ondansetron is available under the following different brand names: Zofran, Zofran ODT, and Zuplenz.What to watch for today What to watch for today Status quo on interest rates. The European Central Bank is expected to hold its policy rate unchanged at a record low of 0.5% (paywa...

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Ondansetron (Zofran) is an antiemetic (or anti-nausea) medication. It's used to prevent nausea and vomiting after surgery or cancer treatments. It works by stopping a chemical called serotonin from binding to receptors in the brain that cause the feeling of nausea and vomiting. Ondansetron (Zofran) is taken by mouth, typically every 8 to 12 ...Apr 10, 2021 ... other, versus no treatment, or versus ... and meclizine. 3.4.2. Serious adverse events ... and ondansetron) and two with moderate certainty evidence ...Anticholinergics decrease the rate of firing in the vestibular nuclei. Although not indicated for vertigo, glycopyrrolate is less sedating than the other drugs used to treat vertigo. 3 Antihistamines, such as meclizine, have anticholinergic effects and are much more sedating than true anticholinergics. Benzodiazepines are effective for vertigo ...Nestlé has issued a voluntary recall of contaminated cookie dough. Surely you know the disappointment of biting into what you think is a chocolate chip cookie only to discover it’s...

In general, Zofran is a more common choice for treating nausea from chemotherapy, radiation, and surgeries. It carries fewer side effects, which makes it a more comfortable treatment option. In addition to having more side effects, Compazine for nausea carries worse side effects as well. Patients are more likely to experience a seizure, liver ...Tranylcypromine: learn about side effects, dosage, special precautions, and more on MedlinePlus A small number of children, teenagers, and young adults (up to 24 years of age) who ...Significant differences were seen in the side-effects between the two groups 30 min (P < 0.001) and 2 h (P < 0.001) after the injections, so that promethazine treatment developed more side-effects than the ondansetron treatment 30 min (58.8% vs. 11.8%) and 2 h (61.2% vs. 12.9%) after the injections. Sleepiness was the most common side-effect in ...Usual Pediatric Dose for Motion Sickness. Age 12 years and older: Initial Dose: 25 to 50 mg orally 1 hour before travel. Maintenance Dose: Repeat dose every 24 hours if needed. Use: Management of nausea, vomiting, and dizziness associated with motion sickness.meclizine (Bonine) promethazine (Phenergan) dimenhydrinate (Dramamine, Gravol) Each can cause side effects, and it is important to speak with a doctor before trying one. ... (Zofran) palonosetron ...For diagnostic laparoscopy (n = 74), fewer patients received escape antiemetic after cyclizine than after ondansetron (4% vs 37%; P < 0.01); for laparoscopic sterilization (n = 101), both antiemetics were equally effective. Ondansetron and cyclizine both reduced severe and moderate nausea and the need for antiemetic therapy after day-case ...Phenergan has an average rating of 7.3 out of 10 from a total of 147 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 23% reported a negative effect. Promethazine has an average rating of 7.3 out of 10 from a total of 380 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 21% reported a negative effect.Ondansetron has an average rating of 7.7 out of 10 from a total of 487 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 19% reported a negative effect. Promethazine has an average rating of 7.3 out of 10 from a total of 380 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 21% reported a negative ...Isopropyl alcohol was provided in the form of a standard alcohol swab. Patients received a single dose of the oral intervention but could sniff alcohol or saline swabs repeatedly. Nausea was measured on a 100-mm visual analog scale at baseline and 30 minutes. Mean nausea scores decreased by 30 mm in the alcohol/ondansetron group, 32 mm in the ...Meclizine, a long-acting drug with a low side-effect profile, may be ideal in combination with ondansetron for at-risk patients. We randomized 77 subjects scheduled for general anesthesia and screened for 4 of 5 PONV risk factors for experimental or control group assignment.Antihistamines include meclizine (Antivert®), dimenhydrinate, diphenhydramine (Benadryl®) and promethazine. ... Dexamethasone (Decadron®) and ondansetron (Zofran®) are powerful and well-established inpatient-setting antiemetics. While not FDA approved, droperidol (Droleptan®) is widely used outside the U.S. The oral agents are only used ...The dosage of ondansetron for this indication is 0.15 mg/kg (32 mg maximum), beginning 30 minutes before administration of chemotherapy and repeated at 4 and 8 hours after the first dose (see Table 79-2). 41 Ondansetron may be administered orally, when possible. For nausea and vomiting occurring or persisting beyond 24 hours after the first ...

The onset of action of meclizine is about 1 hour, with effects lasting between 8 to 24 hours. 4 Meclizine is reported to cause drowsiness due to its anticholinergic actions. 5 Mechanism of action Vomiting is a centrally regulated reflex mechanism that initiates from the vomiting center and the chemoreceptor trigger zone (CTZ) located in the ...

Ondansetron works by blocking some effects of serotonin, a chemical involved in many of your body's functions, including nausea. Ondansetron can sometimes interact with other medications. Several ondansetron interactions are related to its effect on serotonin. And others can raise the risk of heart rhythm problems.The phase IV clinical study is created by eHealthMe based on reports of 139,921 people who take Ondansetron and/or Meclizine hydrochloride, and is updated regularly. You may use the study as a second opinion to make health care decisions. On Jan, 05, 2024. 139,921 people who take Ondansetron and Meclizine hydrochloride are studied.Each patient received ondansetron, corticosteroids, and metoclopramide as prophylactic antiemetics. Forty-six patients developed breakthrough CINV and were treated with olanzapine, 5 mg orally every 12 hours for two doses. Patients were evaluated every six hours for 24 hours. The CR of breakthrough emesis, the control of retching, and nausea ...If it's during normal business hours (8 a.m. to 5 p.m.), please call our office at 1-425-339-5421. Someone on our team can call the pharmacy for you. If you're calling outside of our normal business hours, please call our office at 1-425-339-5421. Select the choice to have our on-call doctor paged.A few OTC treatments are available that can be helpful in relieving nausea, vomiting, and dizziness. Dimenhydrinate (Dramamine) and meclizine (Bonine) are perennial favorites for treating symptoms associated with motion sickness. Emetrol (consisting of dextrose, fructose, and phosphoric acid), can be effective in treating nausea.Comparison of Pregnancy Outcomes of Patients Treated With Ondansetron vs Alternative Antiemetic Medications in a Multinational, Population-Based Cohort (2021) ... Meclizine marketed as Dramamine Low Drowsy. Mother to Baby Fact Sheet (2021) Dramamine or Gravol (Dimenhydrinate) 50-100 mg every 4-6 hours: Used for motion sickness.Ondansetron. Promethazine. Metoclopramide. Prescription only. Ondansetron may be used for the prevention or treatment of nausea and vomiting but it may cause constipation or a headache. Prescribed for Nausea/Vomiting, Gastroenteritis, Alcohol Use Disorder... more. Prescription only. Promethazine may be used to relieve allergy symptoms and nausea.

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More about Meclizine. Ratings & Reviews. Emetrol for Nausea has an average rating of 10.0 out of 10 from a total of 2 ratings on Drugs.com. 100% of reviewers reported a positive effect, while 0% reported a negative effect. Meclizine has an average rating of 7.4 out of 10 from a total of 225 ratings on Drugs.com. 68% of reviewers reported a ...Vertigo is the perception of motion in the absence of movement, which may be described as a sensation of swaying, tilting, spinning, or feeling unbalanced. Due to highly variable descriptions of vertigo, it is often consolidated into the umbrella descriptor 'dizziness', a very common but imprecise complaint that accounts for over three million emergency department (ED) visits annually.[1 ... Side effects may include sedation... more. Meclizine has an average rating of 7.4 out of 10 from a total of 225 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 19% reported a negative effect. Metoclopramide has an average rating of 3.9 out of 10 from a total of 514 ratings on Drugs.com. 29% of reviewers reported a ... Emetrol has an average rating of 8.5 out of 10 from a total of 50 ratings on Drugs.com. 80% of reviewers reported a positive effect, while 10% reported a negative effect. Nauzene has an average rating of 7.8 out of 10 from a total of 26 ratings on Drugs.com. 75% of reviewers reported a positive effect, while 17% reported a negative effect.More about Metoclopramide. Ratings & Reviews. Dimenhydrinate has an average rating of 8.9 out of 10 from a total of 77 ratings on Drugs.com. 88% of reviewers reported a positive effect, while 8% reported a negative effect. Metoclopramide has an average rating of 3.9 out of 10 from a total of 514 ratings on Drugs.com. 29% of reviewers reported a ...Ondansetron (Zofran) is an antiemetic (or anti-nausea) medication. It's used to prevent nausea and vomiting after surgery or cancer treatments. It works by stopping a chemical called serotonin from binding to receptors in the brain that cause the feeling of nausea and vomiting. Ondansetron (Zofran) is taken by mouth, typically every 8 to 12 hours.Drug-Induced Serotonin Syndrome. US Pharm. 2010;35 (11):HS-16-HS-21. A potentially lethal condition, serotonin syndrome (SS) is caused most often when certain antidepressant agents are taken concurrently with other drugs that modulate synaptic serotonin levels. 1,2 When patients take two or more antidepressants from different pharmacologic ...Bonine (meclizine). Although Bonine has little or no chemical structural resemblance to Benadryl/Dramamine its mechanism of action is the same: Histamine H 1 receptor antagonism. Like the others, it too is found in the "least effective" group. ... The discovery of Zofran (ondansetron), a serotonin inhibitor (3), revolutionized chemotherapy ...Zofran. A total of 347 drugs are known to interact with Zofran . Zofran is in the drug class 5HT3 receptor antagonists . Zofran is used to treat the following conditions: Nausea/Vomiting. Nausea/Vomiting, Chemotherapy Induced. Nausea/Vomiting, Postoperative. Nausea/Vomiting, Radiation Induced.Meclizine in combination with ondansetron for prevention of postoperative nausea and vomiting in a high-risk population. Carrie M Forrester Naval Medical Center, Portsmouth, VA, USA.Meclizine Pregnancy Warnings. Animal studies have shown cleft palates at 25 to 50 times the human dose. However, epidemiological studies in pregnant women do not indicate this drug increases the risk of abnormalities when administered during pregnancy. US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to ... ….

The percentage of patients with no vomiting over 0-24 h was significantly higher in both the aprepitant 40 mg (84%) and the aprepitant 125 mg group (86%) than in the ondansetron group (71%); the odds ratios were 2.1 for aprepitant 40 mg vs ondansetron and 2.5 for aprepitant 125 mg vs ondansetron (P < 0.001 for both ratios) (Fig. 3).Phenergan has an average rating of 7.3 out of 10 from a total of 147 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 23% reported a negative effect. Promethazine has an average rating of 7.3 out of 10 from a total of 380 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 21% reported a negative effect.Common treatment involves ondansetron; however, the effects are short-lived, and supplemental medication may be required. Meclizine, a long-acting drug with a low side-effect profile, may be ideal in combination with ondansetron for at-risk patients. We randomized 77 subjects scheduled for general anesthesia and screened for 4 of 5 PONV risk ...Single-dose aprepitant vs ondansetron for the prevention of postoperative nausea and vomiting: a randomized, double-blind phase III trial in patients undergoing open abdominal surgery. ... meclizine, cyclizine, and hydroxyzine have all been used effectively in the treatment of PONV. Promethazine also has significant antihistamine properties ...Comparing Driminate vs Meclizine. Driminate (dimenhydrinate) Meclizine. Prescription and OTC. Prescribed for Nausea/Vomiting, Motion Sickness. Driminate may also be used for purposes not listed in this medication guide. Prescription and OTC.Do not give meclizine to children under the age of 12. 6. Response and effectiveness. Meclizine works in about an hour when used for motion sickness. It should be taken at least an hour before traveling for maximal benefit. The effects of meclizine persist for 8 to 24 hours. 7. Interactions.Meclizine, a long-acting drug with a low side-effect profile, may be ideal in combination with ondansetron for at-risk patients. We randomized 77 subjects scheduled for general anesthesia and screened for 4 of 5 PONV risk factors for experimental or control group assignment. Severity of PONV was measured using a 0 to 10 verbal numeric rating ...Tranylcypromine: learn about side effects, dosage, special precautions, and more on MedlinePlus A small number of children, teenagers, and young adults (up to 24 years of age) who ...5-HT 3 receptor antagonists are recommended as the first-line regimen for PONV prophylaxis. Ondansetron is effective for both the prevention and treatment of PONV without producing significant side effects [].Granisetron, a more selective 5-HT 3 antagonist, has been alleged to produce a sustained antiemetic effect when used for prophylaxis [].White et al. demonstrated that granisetron (1 mg ... Meclizine vs ondansetron, In general, Zofran is a more common choice for treating nausea from chemotherapy, radiation, and surgeries. It carries fewer side effects, which makes it a more comfortable treatment option. In addition to having more side effects, Compazine for nausea carries worse side effects as well. Patients are more likely to experience a seizure, liver ..., Jul 18, 2022 · Promethazine improved vertigo more; ondansetron improved nausea more: Shih et al, 35 2017: US: Double blind: 40: Peripheral: Diazepam (5 mg) vs meclizine (25 mg) (orally) Change in 100-point VAS at 30 and 60 min, reported as mean change: Age 18-65 y; peripheral vertigo as diagnosed by an emergency physician , Postoperative nausea and vomiting (PONV) is a common occurrence following anesthesia and leads to patient dissatisfaction and discomfort. In certain settings, PONV can lead to postoperative complications especially in a patient that cannot tolerate elevated heart rate or blood pressure, intrathoracic pressure, or central venous pressure. Resources report that frequency of PONV is up to 80% in ..., Compare Meclizine vs Ondansetron head-to-head with other drugs for uses, ratings, cost, side effects and interactions., Lower-cost generic is available. Ratings & Reviews. Dexamethasone has an average rating of 5.9 out of 10 from a total of 156 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 36% reported a negative effect. Ondansetron has an average rating of 7.7 out of 10 from a total of 487 ratings on Drugs.com. 73% of reviewers ..., Antiemetics are a class of medications used to treat nausea and vomiting. There are seven classes of antiemetics: antihistamines, like meclizine; anticholinergics, like scopolamine; dopamine antagonists, like promethazine; serotonin antagonists, like ondansetron; cannabinoids, like dronabinol; glucocorticoids, like dexamethasone; and substance P/Neurokinin 1 antagonists, like aprepitant., An interest rate is the cost of borrowing money, or conversely, the income earned from lending money. An interest rate is the cost of borrowing money, or conversely, the income ear..., Meclizine is used to prevent and control nausea, vomiting, and dizziness caused by motion sickness. It is also used for vertigo (dizziness or lightheadedness) caused by ear problems. Meclizine is an antihistamine. It works to block the signals to the brain that cause nausea, vomiting, and dizziness., Do not give meclizine to children under the age of 12. 6. Response and effectiveness. Meclizine works in about an hour when used for motion sickness. It should be taken at least an hour before traveling for maximal benefit. The effects of meclizine persist for 8 to 24 hours. 7. Interactions., Generic Name Tizanidine DrugBank Accession Number DB00697 Background. Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury 9.It may also be caused by musculoskeletal injury 5.Regardless of the cause, muscle spasticity can be an extremely painful and ..., Meclizine effectively reduces N/V associated with emergency hormonal contraception (Yuzpe regimen). There are no adequate reports or well-controlled studies of meclizine in pregnant women. It is commonly used in several European countries for the treatment of 1st trimester N/V., Dramamine (dimenhydrinate) is a popular go-to remedy. It is somewhat effective at reducing motion sickness symptoms, but it is an antihistamine. Like all antihistamines, it may cause drowsiness, dizziness and decreased mental alertness. Some people may experience the exact opposite effects, including insomnia, excitability and restlessness., nausea, rash, vomiting, headache, dry mouth, and. urinary retention. Meclizine also has been associated with hypotension ( low blood pressure) and heart palpitations. This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects., Key takeaways: Several medications can help with nausea from motion sickness. They work best when taken ahead of time to prevent symptoms from happening in the first place. Options include prescription scopolamine patches (Transderm Scop) and over-the-counter antihistamine pills, like dimenhydrinate (Dramamine) and meclizine (Bonine)., Jan 20, 2012 ... Patients who chronically use vestibular suppressants (e.g., meclizine, scopolamine) may become sensitized to these drugs and experience ..., Lower-cost generic is available. Ratings & Reviews. Meclizine has an average rating of 7.4 out of 10 from a total of 225 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 19% reported a negative effect. Dramamine II has an average rating of 9.1 out of 10 from a total of 7 ratings on Drugs.com. 100% of reviewers reported a ..., While the first clinical comparison of SENS‐111 with the H 1 antihistamine meclizine was recently completed confirming that it does not impact vigilance or …, Ondansetron and Dramamine belong to different drug classes. Ondansetron is a serotonin-3 (5-HT3) receptor antagonist, and Dramamine is an antihistamine. Side effects of ondansetron and Dramamine that are similar include drowsiness and constipation. Side effects of ondansetron that are different from Dramamine include headache, feeling unwell ..., Meclizine in combination with ondansetron for prevention of postoperative nausea and vomiting in a high-risk population. Carrie M Forrester Naval Medical Center, Portsmouth, VA, USA., Lower-cost generic is available. Ratings & Reviews. Antivert has an average rating of 7.5 out of 10 from a total of 13 ratings on Drugs.com. 77% of reviewers reported a positive effect, while 23% reported a negative effect. Meclizine has an average rating of 7.4 out of 10 from a total of 225 ratings on Drugs.com. 68% of reviewers reported a ..., Comparing Nausea Control vs Ondansetron. Nausea Control (phosphorated carbohydrate solution) Ondansetron. Over-the-counter. Prescribed for Nausea/Vomiting. Nausea Control may also be used for purposes not listed in this medication guide. Prescription only. Ondansetron may be used for the prevention or treatment of nausea and vomiting but it may ..., Ondansetron is effective in treating nausea and vomiting associated with chemotherapy, which lead to its increased use in treating nausea and vomiting of pregnancy. 9 It is the most commonly used 5-HT 3 antagonist for the treatment of severe NVP, usually when other types of therapy prove ineffective., Promethazine has an average rating of 7.3 out of 10 from a total of 380 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 21% reported a negative effect. Vistaril has an average rating of 5.6 out of 10 from a total of 233 ratings on Drugs.com. 45% of reviewers reported a positive effect, while 39% reported a negative effect., loss of consciousness. mood changes. muscle pain or cramps. nausea or vomiting. noisy breathing. numbness or tingling in the hands, feet, or lips. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. seizures. skin rash, hives, or itching., Meclizine(non-drowsy Dramamine) is the holy grail for me. The patches put me on my ass for a whole day. I was so tired, I face planted in my dinner and then entered the most uncomfortable 16 hour sleep period. I had to take it off to even function. Zofran really only prevents me from throwing up instead of preventing nausea., Identification Summary. Cyclizine is an antihistamine and antiemetic drug used for the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, and vertigo.. Generic Name Cyclizine DrugBank Accession Number DB01176 Background. A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion ..., 5-HT 3 receptor antagonists are recommended as the first-line regimen for PONV prophylaxis. Ondansetron is effective for both the prevention and treatment of PONV without producing significant side effects [].Granisetron, a more selective 5-HT 3 antagonist, has been alleged to produce a sustained antiemetic effect when used for prophylaxis [].White et al. demonstrated that granisetron (1 mg ..., Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking meclizine. You should be warned not to exceed recommended dosages and to avoid activities requiring mental alertness. If your doctor prescribes these medications together, you may need a dose adjustment to safely take this combination., Ondansetron works by blocking some effects of serotonin, a chemical involved in many of your body's functions, including nausea. Ondansetron can sometimes interact with other medications. Several ondansetron interactions are related to its effect on serotonin. And others can raise the risk of heart rhythm problems., meclizine: Blocks H1 receptors and thus blocks ACh in vestibular system: Dopamine (DA2) Dopamine antagonists: prochlorperazine: ... Ondansetron is an example of a serotonin (5HT) antagonist often used to treat severe nausea and vomiting associated with chemotherapy, postoperative nausea and vomiting, and hyperemesis during pregnancy. ..., Ondansetron has an average rating of 7.7 out of 10 from a total of 487 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 19% reported a negative effect. Promethazine has an average rating of 7.3 out of 10 from a total of 380 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 21% reported a negative ..., Meclizine can interact with sleep medications, benzodiazepines, and allergy medications like Benadryl. It can also interact with opioids, dronabinol, and alcohol. Most commonly, these interactions can cause more drowsiness. While some interactions might be mild, others could be potentially dangerous for you., More about Promethazine. Ratings & Reviews. Meclizine has an average rating of 7.4 out of 10 from a total of 225 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 19% reported a negative effect. Promethazine has an average rating of 7.3 out of 10 from a total of 380 ratings on Drugs.com. 65% of reviewers reported a ...