Lamictal weight gain reviews

Antidepressants That Can Cause Weight Gain. Weight gain is one common side effect of certain classes of antidepressants including selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MAOIs). Weight gain is also associated with the atypical antidepressant Remeron (mirtazapine).

Lamictal weight gain reviews. Aim for 300-500 calories per day above your maintenance level for slow weight gain or 700-1,000 calories if you want to gain weight fast. Increase your protein intake

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my neurologist has prescribed Lamotrigine staring at 25mgs for my daily migraines. Does it cause weight gain. I was taking memantine 15mgs for 3 months and gained 25 lbs back pain and edema of my feet and ankles . I cannot lose the weight. I have had bad reactions to all the medications that I have taken over the past 9 years.200-250 mg once per day. 300-400 mg once per day. 400-600 mg once per day. Lamictal XR tablets may be prescribed alone to treat partial-onset seizures in certain adults and children ages 13 ...my neurologist has prescribed Lamotrigine staring at 25mgs for my daily migraines. Does it cause weight gain. I was taking memantine 15mgs for 3 months and gained 25 lbs back pain and edema of my feet and ankles . I cannot lose the weight. I have had bad reactions to all the medications that I have taken over the past 9 years.I'm on Lamictal 300mg & Trintellix 10mg after being on Lexapro for 5 years. I've been on the 10mg does for three weeks, but I haven't felt much difference emotionally. So far I've only experienced very vivid dreams (I'm already a vivid dreamer so it's even more intense), stomach issues the first week, and weight gain.Lamictal and weight gain ?! Jump to Latest Follow This website may include conversations, media, and content around topics relating to eating disorders, trauma, addiction, and mental health. Please be aware that this content may be upsetting, difficult, or triggering for some. EDSF is intended as a place of safety.Lamotrigine for Schizoaffective Disorder User Reviews. Brand names: Lamictal, Lamictal XR, Subvenite, Lamictal ODT, ... No weight gain, no excessive sleep, or any other side effects I can notice. I have actually had a good weight loss since my last increase to 300mg. Don’t know if the two are related but I had been very overweight. I would ...

Customer reviews are an invaluable asset for any business. They provide valuable insights into customer satisfaction, product quality, and the overall customer experience. By lever... Reviews and ratings for Abilify. 1129 reviews submitted with a 6.0 average score. ... No weight gain so far. ... trazodone, fluoxetine, quetiapine, lamotrigine ... Weight gain or weight loss is possible while taking Lamictal. Both were reported as side effects by people taking the drug in clinical studies . Weight loss was slightly more common than weight ...Dosage for manic or mixed episodes in bipolar I disorder. To treat manic or mixed episodes of bipolar I disorder, the typical dosage of Vraylar is between 3 mg and 6 mg once per day. You’ll ...Reviews and ratings for Lamictal. 715 reviews submitted with a 8.0 average score (Page 4). Skip to main content. Search Drugs.com. ... Side effects for me are drowsiness and slight weight gain (8 lbs), I'd gain any amount to feel normal. One VERY important fact to remember is dosage! Everyone has different amounts that work, and don't ever skip ...

Lamictal (lamotrigine) is a mood stabilizer and anticonvulsant prescribed to treat bipolar disorder and epilepsy. This medication can be used to reduce the occurrence of mood episodes in people with bipolar disorder and to control seizures in people with epilepsy. If people suddenly stop taking their medication, they may experience Lamictal ...Reviews and ratings for Aripiprazole. 1469 reviews submitted with a 6.0 average score. ... This last time they put me on abilify in addition to my lamictal and lexapro along with trazadone for sleep. ... No weight gain so far. Decreased appetite. Mild insomnia that seems to be fading after two weeks. Some increased desire to shop, but I'm ...1. Reply. mbarvar • 3 yr. ago. On lamictal and I believe the majority of people on it stay at their weight or lose weight. I think gaining is uncommon—I'd talk to your doctor about it. 2. Reply. Anal-warrior • 3 yr. ago. Theoretical it could be the fault of Lamictal however weight gain is a relatively 'rare' side-effect, first your ...my neurologist has prescribed Lamotrigine staring at 25mgs for my daily migraines. Does it cause weight gain. I was taking memantine 15mgs for 3 months and gained 25 lbs back pain and edema of my feet and ankles . I cannot lose the weight. I have had bad reactions to all the medications that I have taken over the past 9 years.

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Mar 1, 2024 · Children taking valproic acid (Depakote®)— At first, 0.15 mg/kg of body weight of lamotrigine given in one dose or two smaller doses each day for 2 weeks, then 0.3 mg/kg of body weight given in one dose or two smaller doses each day for 2 weeks. After this, your doctor may gradually increase your dose as needed. The adverse effect of lamotrigine (Lamictal) among the options provided is dizziness. This medication often used in the treatment of epilepsy and bipolar disorder, can have a range of side effects. Important side effects of psychiatric medications like antidepressants and antiepileptics can include dizziness, weight gain or loss, and mood ...Reviews and ratings for Oxcarbazepine. 345 reviews submitted with a 7.7 average score. ... I tried Lamotrigine and many antidepressants, all they did was fueled my mild delusional manics and another times was mixed. ... However, I noticed weight gain almost immediately and immense hunger-almost ravenous. When it would wear off I was extremely ...We'll review what Effexor is, the relationship between this medication and weight gain, and common side effects when taking it. ... Weight gain and associated factors in patients using newer antidepressant drugs. (2014.) https://pubmed.ncbi.nlm.nih.gov/25467076/Lithium and lamotrigine were not associated with a statistically significant effect on weight; therefore, they may be weight neutral. ... Second-generation antipsychotic use in schizophrenia and associated weight gain: a critical review and meta-analysis of behavioral and pharmacologic treatments. Ann Clin Psychiatry. 2012; 24:225–239. ...Lamictal withdrawal symptoms include: Seizures, and increased frequency or duration in epileptic persons* 6. Seizures in bipolar persons (non-epileptic persons) 6,7. Anxiety 17. Anhedonia (pervasive loss of the capacity to experience pleasure)11. Rebound, worsening of bipolar symptoms 18.

Lamictal weight gain or loss - Express delivery to Canada - If you buy more than $ 200, we will deliver it for free! 24-hour Support for our clients - The best service from the best Online pharmacy 100% Order Delivery - We are the best in the market! Ga door naar navigatie Ga naar de inhoud.Total: $9,225.00. Continue Shopping. Checkout. Buy Lyrica Tablets Online Pharmacy Sale You should point out to your medical professional any of the following clinical conditions you need to make certain your therapy goes as it needs to Lyrica Generic Name (s): pregabalin . View Free Coupon .Posted by u/Rkzthor - 3 votes and 12 commentsNov 5, 2019 · Unlike most mood stabilizers, though, Lamictal is less likely to cause weight gain. In clinical trials, less than 5 percent of those taking Lamictal gained weight. If you take Lamictal and... Find 1294 user ratings and reviews for Lamictal Oral on WebMD including side effects and drug interactions, medication effectiveness, ease of use and satisfaction ... I would say over the course of 3 weeks. Only side effect was a headache . Did not gain any weight at all and my weight can be up and down. 1. Created with Sketch. Created with ...Lamotrigine did not appear to destabilise mood and was not associated with sexual adverse effects, weight gain, or withdrawal symptoms. ... Hammer A, et al. Stable weight during lamotrigine therapy: a review of 32 studies. Neurology 2000; 54: 973-5. Article PubMed CAS Google Scholar Sachs GS, Guille C. Weight gain associated with use of ...Lamictal User Reviews & Ratings. Lamictal has an average rating of 8.0 out of 10 from a total of 715 reviews on Drugs.com. 76% of reviewers reported a positive experience, while 13% reported a negative experience. Reviews for Lamictal. Top reviews. Most recent. Most helpful. High rating. Low rating. Time … See moreLamotrigine User Reviews & Ratings (Page 2) Brand names: Lamictal, Lamictal XR, Subvenite, Lamictal CD, Lamictal ODT. Lamotrigine has an average rating of 7.8 out of 10 from a total of 1,717 reviews on Drugs.com. 73% of reviewers reported a positive experience, while 16% reported a negative experience.We’ll review what Effexor is, the relationship between this medication and weight gain, and common side effects when taking it. ... Weight gain and associated factors in patients using newer antidepressant drugs. (2014.) https://pubmed.ncbi.nlm.nih.gov/25467076/Lamictal Uses. For those 18 years and older, Lamictal is used for maintenance treatment of bipolar disorder to reduce the occurrence of mood episodes. Although not formally indicated, Lamictal may also be prescribed for other aspects of bipolar disorder and other mood disorders. Lamictal is also used to control seizures in people with epilepsy.I gained 18 pounds in ten months. I follow a strict diet. Low sodium, fruits and veggies for snacks. Salads for lunch, fish twice a week. I started on Lisinopril 10 mgs ten months ago and since then I. have no interset nor strength to do anything. The weight gain and meds are taking a toll on me.

Re: Weight gain and lamictal. Posted by SLS on December 5, 2000, at 17:13:18. In reply to Re: Weight gain and lamictal » Coachnanci, posted by shellie on December 4, 2000, at 16:16:05 > > Has anyone experienced weight gain while on Lamictal. > Nancy, I also gained weight (over ten pounds) while on lamictal.

This Cochrane review involved 11 randomized controlled trials and 2,314 participants. 1 Studies were included if lamotrigine was used as monotherapy, and daily dosages ranged from 100 mg to 500 mg ...Hi everyone. So I’ve recently been prescribed Abilify on top of Lamictal and am so scared about weight gain. I’ll be starting at 2mg Abilify and have…In a 12-week, open-label study, lamotrigine demonstrated a favorable clinical response and was not associated with weight gain in 1137 patients with bipolar I disorder. The results of the present post-hoc analysis are consistent with previous findings that lamotrigine was associated with improved mood symptoms [7] and quality-of-life …Lamictal is rapidly absorbed and peak levels are reached within 1.7 to 4.8 hours of administration. The effects of Lamictal last for over 24 hours and once-daily dosing is often prescribed. However, some doctors prefer to split the dose to decrease the risk of side effects such as drowsiness. 7.Why SSRIs Cause Weight Gain. Weight gain can be a distressing side effect of certain antidepressants in the class of selective serotonin reuptake inhibitors (SSRIs), some of which include Zoloft, …Re: lamictal and weight gain? » nolegirl23. Posted by rina on September 16, 2007, at 22:16:31. In reply to Re: lamictal and weight gain?, posted by nolegirl23 on September 16, 2007, at 20:46:51. that's what i was saying but in different words. lamictal for me causes an increase in appetite but seroquel packs on pounds for me and severe carb cravings. havn't gained weight as a result of ...Re: Lamictal and weight gain? Posted by saw on December 10, 2004, at 1:42:08. In reply to Re: Lamictal and weight gain?, posted by SLS on December 9, 2004, at 20:40:26. I gained 22lb on Effexor and another 11lb on lamictal. I was PROMISED both are weight neutral question00 13 Jan 2010. I have been on Lamictal for about a year and a half. I was told that it does not cause weight gain which attracted me to it. Before Lamictal, I took Seroquel and I gained 40 pounds. Since taking Lamictal, I have actually lost around 20 pounds. Without trying.

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Order Trazodone Pills Express Worldwide Delivery Trazodone is readily available as tablet computers having Fifty Percent mg, 1000 mg, 150 mg and 300 mg of the active ingredient. The causes of adenomas in the stomach are common - heredity, developmental pathologies at the embryonic level, inflammatory diseases, mainly gastritis, junk food, alcoholismThe nurse observes several areas of bruising over soft tissue areas and notes a weight gain of 10 pounds since the last admission 1 year ago. What will the nurse do? ... Review the patient's chart for cytochrome P450 enzymes to see whether an increased dose is needed. ... C Evidence of a rash in a patient taking lamotrigine requires further ...To evaluate the effect of lamotrigine on body weight in adult patients with epilepsy, we conducted a retrospective review of data from 463 patients treated with lamotrigine in 32 clinical trials. Mean daily dose was 259 (±155) mg and duration of therapy was 318 (±87) days. The mean change in body weight was 0.5 (±5) kg.I was prescribed this medication for depression/ anxiety . ( not bipolar disorder ) It has worked very well . A miracle . My doctor started me on 25 and then 50, then 75, then 100 up Until I was on 150 MG, I would say over the course of 3 weeks. Only side effect was a headache . Did not gain any weight at all and my weight can be up and down.ALL psychotropic drugs have the POTENTIAL to cause weight gain. Lamictal is considered weight neutral because it can cause weight gain OR weight loss: LAMICTAL. "Metabolic: Common (1% to 10%): Weight decrease, weight gain". You can minimize the weight gain as you have done, but the metabolic changes are going to …200–250 mg once per day. 300–400 mg once per day. 400–600 mg once per day. Lamictal XR tablets may be prescribed alone to treat partial-onset seizures in certain adults and children ages 13 ...Mild side effects* of Xcopri can include: weight loss. mild drowsiness. dizziness†. fatigue. headache. digestive problems, such as nausea, constipation, diarrhea, or vomiting. Most of these side ...Overall rating 3.3. Effectiveness. Ease of Use. Satisfaction. Worked to help my depression/anxiety but the side effects were hair loss, weight gain, and constipation. I started getting symptoms of hypothyroidism too. Turns out it was causing problems with my biotin/vitamin b intake.There’s no substantial evidence to suggest that Lamictal causes weight gain. The most weight gain reported in a clinical trial participant receiving Lamictal was ~2.2 lbs. (1 kg), and the highest average weight gain in a single trial was 0.68 lbs. In short, Lamictal users are unlikely to experience weight gain as a result of treatment, and if ...Below are answers to commonly asked questions about Lamictal. Can Lamictal be used for weight loss, depression, or anxiety? If so, what is the dosage?Lamictal, generic name lamotrigine, is an anticonvulsant safe for use in adults and children. It is prescribed to people diagnosed with epilepsy who experience focal seizures, tonic-clonic seizures, or other seizures associated with Lennox-Gastaut syndrome (LGS).For those who experience generalized tonic-clonic seizures, Lamictal is considered a first-line treatment. ….

53 dichlorophenyl)-as-triazine, its molecular formula is C9H7N5Cl2, and its molecular weight is 54 256.09. Lamotrigine is a white to pale cream-colored powder and has a pKa of 5.7. Lamotrigine 55 is very slightly soluble in water (0.17 mg/mL at 25°C) and slightly soluble in 0.1 M HCl 56 (4.1 mg/mL at 25°C). The structural formula is:Learn whether to expect weight gain or weight loss when taking Lamictal (lamotrigine), a drug that can be used in the treatment of bipolar disorder and epilepsy. ... Lam I. Efficacy and safety of lamotrigine in the treatment of bipolar disorder across the lifespan: a systematic review. Ther Adv Psychopharmacol. 2021;11:20451253211045870. doi:10 ...Overall rating 4.0. Effectiveness. Ease of Use. Satisfaction. Lamictal has done wonders for my bipolar type 2. Symptoms have decreased dramatically. I have noticed however that I get a funny taste in my mouth on a regular basis (every 2-3 weeks for about a week at a time) and I have muscle tightness in neck and shoulder.Weight gain is the most common metabolic side effect associated with psychiatric medications (see table on next page) Medications affect everyone differently - not everyone will experience the same side effects; Weight gain can lead to problems with blood pressure, cholesterol, or maintaining a regular blood sugarWe would like to show you a description here but the site won’t allow us.When it comes to purchasing a new vehicle, it is crucial to gather as much information as possible before making a decision. One popular luxury SUV that has gained attention in rec...Reviews and ratings for Topamax. 440 reviews submitted with a 5.9 average score. ... For Weight Loss (Obesity/Overweight) ... For Bipolar Disorder "I switched to Topamax from Lamictal to see if it would control my bipolar disorder and help me lose weight. My mood and sleep have been incredible and I have lost 15 lbs in 6 weeks on Topamax.Lamictal is known to be pretty weight neutral and does have a weight loss side effect. At one point, I even started just straight up spooning heavy cream and olive oil into my mouth (not at the same time). It didn't work and my cholesterol is high so I stopped doing that lol. 2. Reply. Lamictal weight gain reviews, Given that so many psychopharmaceutical agents facilitate weight gain, these factors should be reviewed in individual clinical situations . ... gabapentin, and lamotrigine, can cause weight gain (8,24), as shown in Table 1. The valproate-related products are the biggest offenders. Topiramate, however, has been associated with weight loss (35,36 ..., I too gained weight on Viibryd. I understand that this is a relatively unusual side effect, so I wouldn't recommend that anyone avoid trying the drug based on my experience (or on the number of reviews here). That said, I gained about 20 lbs. in roughly 5 months after I started taking this drug., To evaluate the effect of lamotrigine on body weight in adult patients with epilepsy, we conducted a retrospective review of data from 463 patients treated with lamotrigine in 32 clinical trials., Introduction. Bulimia nervosa (BN), characterized in part by regular binge eating and purging, is associated with medical complications, functional impairment, and high rates of mortality and chronicity [1-7].First-line pharmacotherapy (selective serotonin reuptake inhibitors) and psychotherapy (cognitive behavioral therapy) promote full remission in less than half of patients with BN [8, 9]., Lamictal (Lamotrigine) Reviews. 1262 people have reviewed this drug 3.5. 3.5 Stars. Review this Drug . Tips for Good Reviews. ... This combination is better than taking lithium (horrible side effects) or depakote (major weight gain). Report . 0.5 Stars. Posted 226 months ago (6/21/2005) 0., Reviews and ratings for Lamictal when used in the treatment of bipolar disorder. 640 reviews submitted with a 8.2 average score (Page 3). ... Celexa, Prozac, Lithium, Geodon, and Tegretol. Lamictal has been a Godsend. Lamictal has not been associated with weight gain nor diabetes (I have type 2, but was diagnosed prior to my …, Reviews and ratings for BuSpar. 618 reviews submitted with a 5.9 average score. ... the only “side effects” I noticed was a little weight gain and an increase in my sex drive.( which isn’t bad for me and my spouse). I would recommend buspar to anyone. ... Because I also suffer from Bipolar I disorder I also take Lamictal, Provigil, and ..., Lexapro can cause weight gain, especially with long-term use. Learn why this happens and how to manage this side effect. Lexapro can cause weight gain, especially with long-term use. ... One research review found that patients taking Lexapro experienced moderate weight gain of up to 1.83 kilograms (about 4 pounds)., Lamictal for Epilepsy User Reviews. Lamictal has an average rating of 5.5 out of 10 from a total of 19 reviews for the treatment of Epilepsy. 42% of reviewers reported a positive experience, while 42% reported a negative experience. ... gaining even more weight, makes me feel like I'm about to barf sometimes, I get double vision, dizziness, and ..., ALL psychotropic drugs have the POTENTIAL to cause weight gain. Lamictal is considered weight neutral because it can cause weight gain OR weight loss: LAMICTAL. "Metabolic: Common (1% to 10%): Weight decrease, weight gain". You can minimize the weight gain as you have done, but the metabolic changes are going to make losing any more nearly ..., interstelarcloud. •. I’ve gained 60 pounds in one year after my concoction of meds, I was told birth control mixed with certain medications can cause weight gain. I diet and walk/hike a lot and can lose about 2 pounds a month since if I have one night of drinking or a cheat dinner I quickly gain 5-7 pounds (I’m sure it’s water weight also)., Hi! After a really horrible experience on Keppra, I've been put on Lamictal—I had 2 tonic-clinic seizures a few weeks ago, and they haven't given me…, 12/20/2023. Condition: Anxiousness associated with Depression. Overall rating 4.7. Effectiveness. Ease of Use. Satisfaction. This medication saved me from intense anxiety and panic attacks. Occasionally i will have to adjust dosage at stressful times in my life, raising the dosage., 3.3M subscribers in the keto community. The Ketogenic Diet is a low carbohydrate method of eating. /r/keto is place to share thoughts, ideas…, Order Trazodone Pills Express Worldwide Delivery Trazodone is readily available as tablet computers having Fifty Percent mg, 1000 mg, 150 mg and 300 mg of the active ingredient. The causes of adenomas in the stomach are common - heredity, developmental pathologies at the embryonic level, inflammatory diseases, mainly gastritis, junk food, alcoholism, To evaluate the effect of lamotrigine on body weight in adult patients with epilepsy, we conducted a retrospective review of data from 463 patients treated with lamotrigine in 32 clinical trials. Mean daily dose was 259 (±155) mg and duration of therapy was 318 (±87) days. The mean change in body weight was 0.5 (±5) kg., Lamotrigine is extremely unlikely to cause weight gain, but it is possible. I'd say your doctor prescribed it for that reason. Almost all mood stabilisers, except for lamotrigine, cause some weight gain (e.g. lithium, most antipsychotics, sodium valproate). The other mood stabilisers that don't cause weight gain have much more limited efficacy ..., Brand names: Lamictal, Lamictal XR, Subvenite, Lamictal CD, Lamictal ODT. Lamotrigine has an average rating of 8.0 out of 10 from a total of 987 reviews for the treatment of Bipolar Disorder. 77% of reviewers reported a positive experience, while 13% reported a negative experience. Filter by condition., Brand names: Lamictal, Lamictal XR, Subvenite, Lamictal CD, Lamictal ODT. Lamotrigine has an average rating of 9.4 out of 10 from a total of 13 reviews for the off-label treatment of Cyclothymic Disorder. 100% of reviewers reported a positive experience, while 0% reported a negative experience. Filter by condition., Reviews and ratings for Latuda. 790 reviews submitted with a 6.3 average score. ... character flaws I was oblivious to. Active and not in bed all day. Working on dose with psychiatrist still. Using lamictal for moods and gabapentin for anxiety. ... It hasn't caused weight gain like other anti-psychotics, it hasn't caused sleepiness like other ..., Several randomized trials have shown metformin to be effective, but this still hasn't been included in clinical guidelines on managing antipsychotic induced weight gain. Methods: All double blind placebo controlled trials assessing the efficacy of metformin in the treatment of antipsychotic induced weight gain were included. Cochrane Central ..., Aripiprazole (Abilify) is an atypical antipsychotic used to treat different mental health conditions, such as schizophrenia and bipolar I disorder.It works by balancing certain chemicals in the brain to help control thoughts, mood, and behaviors. It's available in many dosage forms, including an oral tablet, solution, and an orally disintegrating tablet (ODT) …, Weight gain or weight loss. Taking Lamictal may lead to weight gain or weight loss. Although rare, weight loss was slightly more common than weight gain in clinical trials for Lamictal., Do not stop taking lamotrigine if you become pregnant. Talk to your doctor, as they may want to review your medicine and may need to change your dose. If you're trying to get pregnant or have become pregnant while taking lamotrigine, your doctor or midwife should recommended that you take a high dose of folic acid (5mg a day). Speak to them ..., Ruxolitinib can cause weight gain by blocking leptin signaling in the brain via JAK2/STAT3 Blood . 2020 Mar 26;135(13):1062-1066. doi: 10.1182/blood.2019003050., Do not stop taking lamotrigine if you become pregnant. Talk to your doctor, as they may want to review your medicine and may need to change your dose. If you're trying to get pregnant or have become pregnant while taking lamotrigine, your doctor or midwife should recommended that you take a high dose of folic acid (5mg a day). Speak to them ..., We would like to show you a description here but the site won’t allow us. , Feb 13, 2018 · Lamotrigine’s favorable tolerability is a welcome advance for patients with bipolar disorder, particularly in the areas that matter most to patients: weight gain, fatigue, sex, and cognition. 1 Unlike other mood stabilizers, lamotrigine lacks long-term medical risks. Rather, the danger it poses is at the start of treatment, when its mood ... , Last updated 2023-09-19. lamictal weight loss reviews Keto Gummies Reviews, (Keto Gummy) weight loss meal plan printable Keto Gummies Scam. Spirits in such a situation where all the people are soldiers, in a mountain range not far from tianyuan city, about three or four hundred monks gathered on ., Customer reviews are an invaluable asset for any business. They provide valuable insights into customer satisfaction, product quality, and the overall customer experience. By lever..., This is the second time I have noticed that the weight increases along with the increase in the dosage of lamotrigine. The last time I lost weight was when I lowered the dosage of lamotrigine. What upset me the most is that it says EVERYWHERE that lamotrigine is not linked to weight gain. Thanks to Reddit, I don't feel crazy., Conclusion: Lamotrigine was associated with stable body weight during 1 year of treatment and was comparable to placebo in mean weight change, incidence of clinically significant weight change, and incidence of weight changes reported as adverse events in patients with bipolar disorder. Lithium was associated with weight gain, but the magnitude ..., Lamictal is known to be pretty weight neutral and does have a weight loss side effect. At one point, I even started just straight up spooning heavy cream and olive oil into my mouth (not at the same time). It didn't work and my cholesterol is high so I stopped doing that lol. 2. Reply.